Publications

                                 

 

 

HIGHLY-CITED REVIEWS:

  1. Winkel BSJ.  2004. Metabolic channeling in plants. Annual Review of Plant Biology, 55: 85-107
  2. Winkel-Shirley B. 2002. Biosynthesis of flavonoids and effects of stress. Current Opinion in Plant Biology, 5: 218-223
  3. Winkel-Shirley B.  2001. Flavonoid biosynthesis: a colorful model for genetics, biochemistry, cell biology and biotechnology. Plant Physiology, 126: 485–493
  4. Winkel-Shirley B. 2001. It takes a garden: How work on diverse plant species has contributed to an understanding of flavonoid metabolism. Plant Physiology, 127: 1399-1404

FLAVONOID METABOLISM (Selected):

  1. Hildreth SB, Littleton ES, Clark LC, Puller GC, Kojima S, Winkel BSJ. 2021. Mutations that alter Arabidopsis flavonoid metabolism affect the circadian clock. The Plant Journal 110, 932-945
  2. SB Hildreth, EE Foley, GK Muday, RF Helm, BSJ Winkel. 2020. The dynamic response of the Arabidopsis root metabolome to auxin and ethylene is not predicted by changes in the transcriptome. Scientific reports 10, 1-15
  3. Hamamouch N, Winkel BSJ, Li C, Davis E. 2020. Modulation of Arabidopsis flavonol biosynthesis genes by cyst and root-knot nematodes. Plants, 9: 253.
  4. Winkel BSJ. 2019. The subtleties of subcellular distribution. Recent Advances in Polyphenol Research. 6: 89-107
  5. Winkel BSJ. 2018. Charting blackwater rivers. Nature Plants, 4: 987
  6. Watkinson JI, Bowerman PA, Crosby KC, Hildreth SB, Helm RF, Winkel BSJ. 2018. Identification of MOS9 as an interaction partner for chalcone synthase in the nucleus. PeerJ, 6: e5598
  7. Winkel BSJ. 2017. When an enzyme isn’t just an enzyme anymore. Journal of Experimental Botany, 68: 1387-1389
  8. Hood MI, Winkel BSJ, and Pelletier MK. 2014. Fine scale genetic mapping of the TT9 locus of Arabidopsis thaliana. Journal of Plant Biochemistry and Physiology, 2: 128
  9. Bowerman PA, Ramirez MV, Moore M, Helm RF, Winkel BSJ. 2012. Analysis of T-DNA alleles of flavonoid biosynthesis genes in Arabidopsis ecotype Columbia. BMC Research Notes, 5: 48 (note: a critical correction in numbering of the tt4 alleles has been made in Bowerman 2012 corrections highlighted 2023-03-03)
  10. Crosby KC, Pietraszewska A, Gadella TWJ Jr, and Winkel BSJ. 2011.  Förster resonance energy transfer (FRET) analysis demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes. FEBS Letters, 585: 2193-2198
  11. Owens DK, Alerding AW, Crosby KC, Bandara AB, Westwood JH, Winkel BSJ. 2008. Functional analysis of a predicted flavonol synthase gene family in Arabidopsis. Plant Physiology, 147: 1046-1061
  12. Owens DK, Crosby KC, Runac J, Howard BA, Winkel BSJ. 2008. Characterization of flavanone 3β-hydroxylase from Arabidopsis thaliana.  Plant Physiology and Biochemistry, 46: 833-843
  13.  Saslowsky DE, Warek U, Winkel BSJ. 2005. Nuclear localization of flavonoid enzymes in Arabidopsis. Journal of Biological Chemistry 280: 23735-23740
  14.  Burbulis IE, Winkel-Shirley B. Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway. 1999. Proceedings of the National Academy of Sciences, 96: 12929-12934
  15. Shirley BW, Kubasek WL, Storz G, Bruggemann E, Koornneef M, Ausubel FM, Goodman HM. 1995. Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis. The Plant Journal, 8:, 659-671
  16. Shirley BW, Hanley S, Goodman HM. 1992. Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. The Plant Cell, 4: 333-347

SYSTEMS-LEVEL ANALYSIS OF THE AUXIN/ETHYLENE RESPONSE:

  1. Hildreth SB, Foley EE, Muday GK, Helm RF, Winkel BSJ. 2020. The dynamic response of the Arabidopsis root metabolome to auxin and ethylene is not predicted by changes in the transcriptome.  Scientific Reports 10: 679.
  2. Slade WO, Ray WK, Williams PM, Winkel BSJ, Helm RF. 2013. Effects of exogenous auxin and ethylene on the Arabidopsis root proteome. Phytochemistry, 84:18-23
  3. Vallabhaneni P, Ray WK, Winkel BSJ, Helm RF. 2012. Characterization of flavonol glycosides in individual Arabidopsis root tips by flow injection electrospray mass spectrometry.  Phytochemistry, 73: 114-118
  4. Lewis DR, Ramirez MV, Miller ND, Vallabhaneni P, Ray WK, Helm RF, Winkel BSJ, Muday GK. 2011. Auxin and ethylene induce distinct flavonol accumulation through distinct transcriptional networks.  Plant Physiology, 156: 144-164

MULTIMETALLIC ANTI-CANCER AGENTS (Selected):

  1. Jain A, Winkel BSJ, Brewer KJ. 2022. Photodynamic antimicrobial studies on a Ruthenium-based metal complex. Inorganica Chimica Acta 538: 120996
  2. Rodríguez-Corrales JÁ, Wang J, Winkel BSJ, Brewer KJ. 2018. Mechanistic investigation into DNA modification by a RuII,RhIII Bimetallic Complex. ChemBioChem, 19: 2216-2224
  3. Zhu J, Rodríguez-Corrales JÁ, Prussin R, Zhao Z, Dominijanni A, Hopkins SL, Winkel BSJ, Robertson JL, Brewer KJ. 2017. Exploring the activity of a polyazine bridged Ru (ii)–Pt (ii) supramolecule in F98 rat malignant glioma cells. Chemical Communications, 53: 145-148
  4.  SL Hopkins, L Stepanyan, N Vahidi, A Jain, BSJ Winkel, KJ Brewer. 2017. Visible light induced antibacterial properties of a Ru (II)–Pt (II) bimetallic complex. Inorganica Chimica Acta, 454: 229-233
  5. Padilla R, Maza WA, Dominijanni AJ, Winkel BSJ, Morris AJ, Brewer KJ. 2016. Pushing the limits of structurally-diverse light-harvesting Ru (II) metal-organic chromophores for photodynamic therapy. Journal of Photochemistry and Photobiology A: Chemistry, 322: 67-75
  6. Padilla R, Rodriguez-Corrales JA, Donohoe LE, Winkel BSJ, Brewer KJ. 2016. A new class of Ru (II) polyazine agents with potential for photodynamic therapy. Chemical Communications, 52: 2705-2708
  7. Wang J, Newman J, Higgins SLH, Brewer KM, Winkel BSJ, Brewer KJ. 2013. Red-light-induced inhibition of DNA replication and amplification in PCR with an Os/Rh supramolecule. Angewandte Chemie International Edition, 52:1262-1265
  8. Wang J, Zigler DF, Hurst N, Othee H, Winkel BSJ, Brewer KJ. 2012. A new, bioactive structural motif: visible light induced DNA photobinding and oxygen independent photocleavage by RuII,RhIII bimetallics. Journal of Inorganic Chemistry, 116: 135-139
  9. Higgins SLH, Tucker AJ, Winkel BSJ, Brewer KJ. 2012. Metal to ligand charge transfer induced DNA photobinding in a Ru(II)-Pt(II) supramolecule using red light in the therapeutic window: a new mechanism for DNA modification. Chemical Communications 48: 67-69
  10. Wang J, Higgins SLH, Winkel BSJ, Brewer KJ. 2011. A New Os,Rh Bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation.  Chemical Communications 47: 9786-9788

Department of Biological Sciences, Virginia Tech